Synthesis of Some Pyridazinylacetic Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors

Sherine Nabil Khattab; Adnan Ahmed Bekhit; Ayman El-Faham; Abdel Moneim El Massry; Adel Amer

doi:10.1248/cpb.56.1717

Notes

Synthesis of Some Pyridazinylacetic Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors

Sherine Nabil Khattab, Adnan Ahmed Bekhit, Ayman El-Faham, Abdel Moneim El Massry, Adel Amer

著者情報

キーワード: monoamine oxidase inhibitor, pyridazine, acetic acid, amino acid

ジャーナルフリー

2008 年 56 巻 12 号 p. 1717-1721

DOI https://doi.org/10.1248/cpb.56.1717

詳細

抄録

A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）