Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids

Kazuhito Hioki; Yumiko Takechi; Noriyo Kimura; Hiroyuki Tanaka; Munetaka Kunishima

doi:10.1248/cpb.56.1735

Notes

Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids

Kazuhito Hioki, Yumiko Takechi, Noriyo Kimura, Hiroyuki Tanaka, Munetaka Kunishima

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Keywords: oxazoline, carboxylic acid, 2-haloethylammonium salt, dehydrocondensation, cyclization

JOURNAL FREE ACCESS

2008 Volume 56 Issue 12 Pages 1735-1737

DOI https://doi.org/10.1248/cpb.56.1735

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Abstract

Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.

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