Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Application of Partial Least Square on Quantitative Analysis of L-, D-, and DL-Tartaric Acid by Terahertz Absorption Spectra
Rika Nishikiori, Mariko Yamaguchi, Keisuke Takano, Tokujiro Enatsu, Masahiko Tani, U. Chandimal de Silva, Norihito Kawashita, Tatsuya Takagi, Shotaro Morimoto, Masanori Hangyo, Masaya Kawase
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2008 年 56 巻 3 号 p. 305-307

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Absorption spectra of polycrystalline L-, D-, and DL-tartaric acid have been measured by terahertz time domain spectroscopy (THz-TDS). Different absorption bands are observed for DL-tartaric acid and its enantiomers (L- and D-tartaric acid). This result shows that the THz-TDS can be used for distinguishing between DL-tartaric acid and enantiomers (L- and D-tartaric acid). Moreover, partial least square (PLS) can be found to improve the quantitation of L-tartaric acid in L- and DL-tartaric acid mixture by THz-TDS.
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© 2008 The Pharmaceutical Society of Japan
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