Practical Synthesis of a Key Intermediate for Lactacystin from (R)-4-Hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl Acetate

Hiroaki Miyaoka; Makoto Yamanishi; Ayako Hoshino; Hidemichi Mitome; Etsuko Kawashima

doi:10.1248/cpb.56.738

Notes

Practical Synthesis of a Key Intermediate for Lactacystin from (R)-4-Hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl Acetate

Hiroaki Miyaoka, Makoto Yamanishi, Ayako Hoshino, Hidemichi Mitome, Etsuko Kawashima

著者情報

キーワード: lactacystin, formal synthesis, α-substituted α-amino acid, chiral building block, proteasome inhibitor

ジャーナルフリー

2008 年 56 巻 5 号 p. 738-741

DOI https://doi.org/10.1248/cpb.56.738

詳細

抄録

A practical synthesis of a key intermediate for the proteasome inhibitor lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate was established. (R)-4-Hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate is a useful chiral building block for the synthesis of biologically active compounds containing α-substituted α-amino acid moieties.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）