Novel Norhumulene and Xeniaphyllane-Derived Terpenoids from a Formosan Soft Coral Sinularia gibberosa

Shin-Pin Chen; Jui-Hsin Su; Hsiao-Chien Yeh; Atallah Fouad Ahmed; Chang-Feng Dai; Yang-Chang Wu; Jyh-Horng Sheu

doi:10.1248/cpb.57.162

Regular Articles

Novel Norhumulene and Xeniaphyllane-Derived Terpenoids from a Formosan Soft Coral Sinularia gibberosa

Shin-Pin Chen, Jui-Hsin Su, Hsiao-Chien Yeh, Atallah Fouad Ahmed, Chang-Feng Dai, Yang-Chang Wu, Jyh-Horng Sheu

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Keywords: diterpenoid, xeniaphyllane, Sinularia gibberosa, cytotoxic

JOURNAL FREE ACCESS

2009 Volume 57 Issue 2 Pages 162-166

DOI https://doi.org/10.1248/cpb.57.162

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Abstract

A novel skeletal norhumulene (1) and six xeniaphyllane-derived compounds, including norditerpenoids (2, 3) and diterpenoids (4—7), were isolated from the EtOAc extract of the Formosan soft coral Sinularia gibberosa. Their structures were elucidated by spectroscopic analysis. In vitro cytotoxic evaluation of the above metabolites revealed that 2 and 4 showed weak cytotoxicity toward a few cancer cell lines.

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