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Chemical and Pharmaceutical Bulletin
Vol. 58 (2010) No. 3 P 381-385

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http://doi.org/10.1248/cpb.58.381

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Chemical investigations of the Formosan soft coral Lemnalia flava have obtained a new ylangene-type sesquiterpenoid, (1S,2S,4R,6S,7R,8S)-4α-formyloxy-β-ylangene (1), along with two known sesquiterpenoids, lemnalol (2) and isolemnalol (3). Three new nardosinane-type sesquiterpenoids, designated as paralemnolins J—L (4—6), and five known sesquiterpenoids (7—11), were isolated from the other soft coral Paralemnalia thyrsoides. The structures of metabolites 1 and 4—6 were elucidated through extensive spectroscopic analysis and chemical methods. Moreover, the anti-inflammatory activity of metabolites 1—7 and 11 was evaluated in vitro.

Copyright © 2010 The Pharmaceutical Society of Japan

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