A Hepatitis B Virus Inhibitory Neolignan from Herpetospermum caudigerum

Fan Yang; Hong-Jun Zhang; Yuan-Yuan Zhang; Wan-Sheng Chen; Hai-Long Yuan; Hou-Wen Lin

doi:10.1248/cpb.58.402

Notes

A Hepatitis B Virus Inhibitory Neolignan from Herpetospermum caudigerum

Fan Yang, Hong-Jun Zhang, Yuan-Yuan Zhang, Wan-Sheng Chen, Hai-Long Yuan, Hou-Wen Lin

Author information

Keywords: Herpetospermum caudigerum, herpepropenal, hepatitis B virus inhibition, neolignan

JOURNAL FREE ACCESS

2010 Volume 58 Issue 3 Pages 402-404

DOI https://doi.org/10.1248/cpb.58.402

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Abstract

A new dihydrobenzofuran neolignan, herpepropenal, was isolated from the seeds of Herpetospermum caudigerum. Its chemical structure was established based on spectroscopic analysis. In this work, the inhibitory effects of herpepropenal on hepatitis B virus DNA and on the replication and expression of hepatitis B surface antigen and hepatitis B e antigen were also evaluated. The new compound exhibited inhibitory effects against hepatitis B virus.

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