Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia
Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Ninh Khac Ban, Nguyen Xuan Cuong, Nguyen Huu Tung, Le Minh Ha, Do Thi Ha, Bui Huu Tai, Tran Hong Quang, Tran Minh Ngoc, Young-In Kwon, Hae-Dong Jang, Young Ho Kim
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キーワード: Momordica charantia, Cucurbitaceae, cucurbitane-type triterpene glycoside, charantoside, α-glucosidase
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2010 年 58 巻 5 号 p. 720-724

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Fourteen cucurbitane-type triterpene glycosides (1—14) were isolated from a methanol extract of Momordica charantia fruits, including three new compounds, charantosides A—C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6—11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.
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© 2010 The Pharmaceutical Society of Japan
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