Identification of Mutaprodenafil in a Dietary Supplement and Its Subsequent Synthesis

Yosuke Demizu; Daigo Wakana; Hiroyuki Kamakura; Masaaki Kurihara; Haruhiro Okuda; Yukihiro Goda

doi:10.1248/cpb.59.1314

Communication to the Editor

Identification of Mutaprodenafil in a Dietary Supplement and Its Subsequent Synthesis

Yosuke Demizu, Daigo Wakana, Hiroyuki Kamakura, Masaaki Kurihara, Haruhiro Okuda, Yukihiro Goda

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Keywords: aildenafil prodrug, sildenafil analogue, mutaprodenafil, phosphodiesterase-5 inhibitor, erectile dysfunction

JOURNAL FREE ACCESS

2011 Volume 59 Issue 10 Pages 1314-1316

DOI https://doi.org/10.1248/cpb.59.1314

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Abstract

We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.

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