Halioxepine, a New Meroditerpene from an Indonesian Sponge Haliclona sp.

Agus Trianto; Idam Hermawan; Nicole Joy de Voogd; Junichi Tanaka

doi:10.1248/cpb.59.1311

Notes

Halioxepine, a New Meroditerpene from an Indonesian Sponge Haliclona sp.

Agus Trianto, Idam Hermawan, Nicole Joy de Voogd, Junichi Tanaka

Author information

Keywords: marine natural product, sponge, antioxidant activity, cytotoxicity, 1,1-diphenyl-2-picrylhydrazyl, NBT-T2

JOURNAL FREE ACCESS

2011 Volume 59 Issue 10 Pages 1311-1313

DOI https://doi.org/10.1248/cpb.59.1311

Details

Abstract

Chemical investigations on a sponge Haliclona sp. found a meroditerpene 1 having a new carbon skeleton. By analyzing spectroscopic data, the structure was elucidated to comprise a substituted hydroquinone, a tetrahydrooxepine, and a cyclohexene, and these components were united with C1 and C2 units. Compound 1 showed moderate cytotoxicity against NBT-T2 cells with IC₅₀ 4.8 μg/ml and also antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC₅₀ 3.2 μg/ml.

Corresponding author

Register with J-STAGE for free!