Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor

Yumiko Nagasawa; Reiko Ueoka; Rumi Yamanokuchi; Naoki Horiuchi; Tsuyoshi Ikeda; Henki Rotinsulu; Remy E. P. Mangindaan; Kazuyo Ukai; Hisayoshi Kobayashi; Michio Namikoshi; Hiroshi Hirota; Hideyoshi Yokosawa; Sachiko Tsukamoto

doi:10.1248/cpb.59.287

Notes

Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor

Yumiko Nagasawa, Reiko Ueoka, Rumi Yamanokuchi, Naoki Horiuchi, Tsuyoshi Ikeda, Henki Rotinsulu, Remy E. P. Mangindaan, Kazuyo Ukai, Hisayoshi Kobayashi, Michio Namikoshi, Hiroshi Hirota, Hideyoshi Yokosawa, Sachiko Tsukamoto

著者情報

キーワード: tetrahydroisoquinoline alkaloid, proteasome, chymotrypsin-like activity, marine sponge

ジャーナルフリー

2011 年 59 巻 2 号 p. 287-290

DOI https://doi.org/10.1248/cpb.59.287

詳細

抄録

Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC₅₀ values of 50 and 32 μg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 μg/ml.

責任著者(Corresponding author)

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