Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba

Ahmad Kaleem Qureshi; Mat Ropi Mukhtar; Yusuke Hirasawa; Takahiro Hosoya; Alfarius Eko Nugroho; Hiroshi Morita; Osamu Shirota; Khalit Mohamad; A. Hamid A. Hadi; Marc Litaudon; Khalijah Awang

doi:10.1248/cpb.59.291

Notes

Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba

Ahmad Kaleem Qureshi, Mat Ropi Mukhtar, Yusuke Hirasawa, Takahiro Hosoya, Alfarius Eko Nugroho, Hiroshi Morita, Osamu Shirota, Khalit Mohamad, A. Hamid A. Hadi, Marc Litaudon, Khalijah Awang

著者情報

キーワード: neolamarckine, indole, Neolamarckia cadamba, Rubiaceae, inducible nitric oxide synthase activity

ジャーナルフリー

2011 年 59 巻 2 号 p. 291-293

DOI https://doi.org/10.1248/cpb.59.291

詳細

抄録

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

責任著者(Corresponding author)

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