Cladieunicellins A—E, New Eunicellins from an Indonesian Soft Coral Cladiella sp.

Yung-Husan Chen; Chia-Ying Tai; Yueh-Hsiung Kuo; Chia-Ying Kao; Jan-Jung Li; Tsong-Long Hwang; Lee-Shing Fang; Wei-Hsien Wang; Jyh-Horng Sheu; Ping-Jyun Sung

doi:10.1248/cpb.59.353

Regular Articles

Cladieunicellins A—E, New Eunicellins from an Indonesian Soft Coral Cladiella sp.

Yung-Husan Chen, Chia-Ying Tai, Yueh-Hsiung Kuo, Chia-Ying Kao, Jan-Jung Li, Tsong-Long Hwang, Lee-Shing Fang, Wei-Hsien Wang, Jyh-Horng Sheu, Ping-Jyun Sung

Author information

Yung-Husan Chen
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Chia-Ying Tai
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Yueh-Hsiung Kuo
Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University
Chia-Ying Kao
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Jan-Jung Li
National Museum of Marine Biology and Aquarium, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, Chang Gung University
Lee-Shing Fang
Department of Sport, Health, and Leisure, Cheng Shiu University
Wei-Hsien Wang
National Museum of Marine Biology and Aquarium, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
Asia-Pacific Ocean Research Center, National Sun Yat-sen University
Jyh-Horng Sheu
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
Asia-Pacific Ocean Research Center, National Sun Yat-sen University
Ping-Jyun Sung
National Museum of Marine Biology and Aquarium, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
Asia-Pacific Ocean Research Center, National Sun Yat-sen University
Department of Life Science and the Institute of Biotechnology, National Dong Hwa University

Keywords: cladieunicellin, eunicellin, soft coral, Cladiella, cytotoxicity, superoxide anion

JOURNAL FREE ACCESS

2011 Volume 59 Issue 3 Pages 353-358

DOI https://doi.org/10.1248/cpb.59.353

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Abstract

Five new eunicellin-type diterpenoids, cladieunicellins A—E (1—5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1—5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

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