Ceramicines E—I, New Limonoids from Chisocheton ceramicus

Chin Piow Wong; Misae Shimada; Yuta Nagakura; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Khalijah Awang; A. Hamid A. Hadi; Khalit Mohamad; Motoo Shiro; Hiroshi Morita

doi:10.1248/cpb.59.407

Notes

Ceramicines E—I, New Limonoids from Chisocheton ceramicus

Chin Piow Wong, Misae Shimada, Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Khalijah Awang, A. Hamid A. Hadi, Khalit Mohamad, Motoo Shiro, Hiroshi Morita

著者情報

キーワード: limonoid, Chisocheton ceramicus, ceramicine, cytotoxic activity

ジャーナルフリー

2011 年 59 巻 3 号 p. 407-411

DOI https://doi.org/10.1248/cpb.59.407

詳細

抄録

Five new limonoids, ceramicines E—I (1—5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E—I (1—5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.

責任著者(Corresponding author)

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