Notes
Practical Preparation of Ethyl 2-Methylthiophene-3-carboxylate
2011 年 59 巻 6 号 p. 797-798
詳細
2011 年 59 巻 6 号 p. 797-798
A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.
