Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

Hairin Taha; A. Hamid A. Hadi; Noraziah Nordin; Ibrahim A. Najmuldeen; Khalit Mohamad; Osamu Shirota; Alfarius E. Nugroho; Wong Chin Piow; Toshio Kaneda; Hiroshi Morita

doi:10.1248/cpb.59.896

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Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

Hairin Taha, A. Hamid A. Hadi, Noraziah Nordin, Ibrahim A. Najmuldeen, Khalit Mohamad, Osamu Shirota, Alfarius E. Nugroho, Wong Chin Piow, Toshio Kaneda, Hiroshi Morita

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Keywords: pseuduvarine A, pseuduvarine B, dioxoaporphine, Pseuduvaria rugosa, cytotoxic activity

JOURNAL FREE ACCESS

2011 Volume 59 Issue 7 Pages 896-897

DOI https://doi.org/10.1248/cpb.59.896

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Abstract

Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC₅₀, 0.9, 21.7, and >50.0 μM, respectively, 2: IC₅₀ >50.0, 15.7, and 12.4 μM, respectively).

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