Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
Two New Cytotoxic Phenylallylflavanones from Mexican Propolis
Feng LiYu-Min HeSuresh AwaleShigetoshi KadotaYasuhiro Tezuka
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2011 Volume 59 Issue 9 Pages 1194-1196

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Abstract

Two new phenylallylflavanones, (2R,3R)-6-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]pinobanksin (1) and (2R,3R)-6-[1-(4′-hydroxy-3′-methoxyphenyl)prop-2-en-1-yl]pinobanksin 3-acetate (2) were isolated from a methanolic extract of Mexican propolis. Their structures were elucidated with spectroscopic analysis. Both compounds (1, 2) exhibited preferential cytotoxic activity against PANC-1 human pancreatic cancer cells in a nutrient-deprived medium with the concentration at which 50% cells died preferentially in NDM (PC50) values of 17.9 μM and 9.1 μM, respectively.

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© 2011 The Pharmaceutical Society of Japan
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