The Effect of Submicron Emulsion Systems on Transdermal Delivery of Kaempferol

Abstract

In this study, submicron emulsions have been employed as a carrier for the topical application of kaempferol. The effect of components of submicron emulsions on the physicochemical properties and permeation capability of drug were evaluated. In case of drug-loaded submicron emulsions, the cumulative amount over 12 h (Q_12 h), lag time and deposition in skin amount ranged from 13.0±3.4 to 236.1±21.2 µg/cm², 1.7 to 5.3 h, and 1.10 to 7.76 µg/cm², respectively, which indicated that the permeation parameters of kaempferol were markedly influenced by the component ratio. Kaempferol dispensed in isopropyl myristate was used as the control. The Q_12 h, lag time and deposition amount in skin were 4.2±1.8 µg/cm², 6.0 h and 2.25±0.60 µg/cm², respectively. The data showed that used appropriate submicron emulsions as vehicle could significantly increase the Q_12 h and deposition amount in skin and shorten the lag time, demonstrating that submicron emulsions have a potent enhancement effect for kaempferol transdermal delivery.