Himeic Acids E–G, New 4-Pyridone Derivatives from a Culture of Aspergillus sp.

Abstract

Three new himeic acids E–G were isolated from a marine-derived fungus, Aspergillus sp., and their structures were determined by spectroscopic analysis. Although himeic acid A inhibited the activity of ubiquitin-activating enzyme (E1), the three new derivatives did not.