Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles

Mukkara Swapna; Chokkappagari Premakumari; Sanapalli Nagi Reddy; Adivireddy Padmaja; Venkatapuram Padmavathi; Paturu Kondaiah; Narra Siva Krishna

doi:10.1248/cpb.c13-00218

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Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles

Mukkara Swapna, Chokkappagari Premakumari, Sanapalli Nagi Reddy, Adivireddy Padmaja, Venkatapuram Padmavathi , Paturu Kondaiah, Narra Siva Krishna

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Keywords: 1,3,4-oxadiazole, 1,3,4-thiadiazole, pyrrole, pyrazole, antimicrobial activity, cytotoxicity

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2013 Volume 61 Issue 7 Pages 722-730

DOI https://doi.org/10.1248/cpb.c13-00218

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Abstract

A new class of sulfonamidomethane pyrrolyl–oxadiazoles/thiadiazoles and pyrazolyl–oxadiazoles/thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penicillium chrysogenum. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.

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