Study on Antitubercular Constituents from the Seeds of Nigella glandulifera

Lian-li Sun; Ming Luan; Wei Zhu; Shuai Gao; Qian-lan Zhang; Chan-juan Xu; Xiang-hong Lu; Xiang-dong Xu; Jing-kui Tian; Lin Zhang

doi:10.1248/cpb.c13-00216

Notes

Study on Antitubercular Constituents from the Seeds of Nigella glandulifera

Lian-li Sun, Ming Luan, Wei Zhu, Shuai Gao, Qian-lan Zhang, Chan-juan Xu, Xiang-hong Lu, Xiang-dong Xu, Jing-kui Tian, Lin Zhang

Author information

Lian-li Sun
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
Ming Luan
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
College of Pharmacy, Shandong University of Traditional Chinese Medicine
Wei Zhu
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
Shuai Gao
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
College of Pharmacy, Shandong University of Traditional Chinese Medicine
Qian-lan Zhang
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
Chan-juan Xu
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
Xiang-hong Lu
Lishui People's Hospital
Xiang-dong Xu
Lishui People's Hospital
Jing-kui Tian
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University
Lin Zhang Corresponding author
The Key Laboratory of Biomedical Engineering of Ministry of Education, P. R. China, Department of Biomedical Engineering, Zhejiang University

Keywords: Nigella glandulifera, methoxynigeglanine, phenolic glycoside, antitubercular activity

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2013 Volume 61 Issue 8 Pages 873-876

DOI https://doi.org/10.1248/cpb.c13-00216

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Abstract

Two new compounds with five known compounds have been isolated from EtOH extract of the seeds of Nigella glandulifera. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as methoxynigeglanine (1) and 6-methoxythymol-3-O-β-D-glucopyranoside (4). Compounds 1–4 showed moderate antitubercular activity against Mycobacterium tuberculosis strain H37Rv with minimal inhibitory concentration (MIC) values of 32–250 µg/mL.

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