Synthesis and Antiviral Activities of Some 2,4,6-Trisubstituted 1,3,5-Triazines

Abstract

We describe the synthesis and results of biological evaluation of newly designed 2,4,6-trisubstituted symmetrical 1,3,5-triazine (TAZ) derivatives. Among the tested trisubstituted TAZ derivatives, some C_S-symmetrical alkoxy-amino-substituted TAZ derivatives, including 7ggp and 6dpp, showed significant antiviral activity against herpes simplex virus type 1 (HSV-1). The compound with the highest level of antiviral activity was C₃-symmetrical trialkoxy-TAZ derivative 4bbb, which showed a considerably high selectivity index (IC₅₀/EC₅₀=256.6). The structure–activity relationships for anti-HSV-1 activity of the tested 2,4,6-trisubstituted TAZ derivatives are also described.