Review
Total Synthesis of Biologically Active Natural Products Based on Highly Selective Synthetic Methodologies
2014 年 62 巻 11 号 p. 1045-1061
詳細
2014 年 62 巻 11 号 p. 1045-1061
Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita–Baylis–Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C–H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.
