Synthesis and Anticancer Activity of Novel Deoxoartemisinin–Glycolipid Hybrids

Abstract

The practical synthesis and anticancer activity of novel deoxoartemisinin–glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin–glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.