Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

This article has now been updated. Please use the final version.

Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids
Dongguk Min, Minkyu Kim, Jérémy Ricci, Sora Jung, Kirim Kim, Won-Yoon Chung, Kwang-Kyun Park, Mankil Jung
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Keywords: Anticancer activity, oral squamous carcinoma, deoxoartemisinin, glycolipid hybrid
JOURNAL FREE ACCESS Advance online publication

Article ID: c14-00036

The final version of this article is now available: Vol. 62 (2014), No. 5 pp. 446-453
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Abstract
The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which
incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin-glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.
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© 2014 The Pharmaceutical Society of Japan
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