Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Enhancement of TFO Triplex Formation by Conjugation with Pyrene via Click Chemistry
Yosuke TaniguchiAkira TomizakiNozomu MatsuedaHidenori OkamuraShigeki Sasaki
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Volume 63 (2015) Issue 11 Pages 920-926

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Abstract

This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-O-methyl-1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.

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© 2015 The Pharmaceutical Society of Japan
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