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Chemical and Pharmaceutical Bulletin
Vol. 63 (2015) No. 11 p. 920-926

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http://doi.org/10.1248/cpb.c15-00570

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This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-O-methyl-1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.
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Copyright © 2015 The Pharmaceutical Society of Japan

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