Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard)

Le Son Hoang; Manh Hung Tran; Joo Sang Lee; Dao Cuong To; Van Thu Nguyen; Jeong Ah Kim; Jeong Hyung Lee; Mi Hee Woo; Byung Sun Min

doi:10.1248/cpb.c14-00855

Notes

Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard)

Le Son Hoang, Manh Hung Tran, Joo Sang Lee, Dao Cuong To, Van Thu Nguyen, Jeong Ah Kim, Jeong Hyung Lee, Mi Hee Woo, Byung Sun Min

Author information

Keywords: Madhuca pasquieri, Sapotaceae, lindelofidine-1-hydroxymethyl pyrrolizidine

JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2015 Volume 63 Issue 6 Pages 481-484

DOI https://doi.org/10.1248/cpb.c14-00855

Details

Abstract

A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.

Graphical Abstract Fullsize Image

Corresponding author

Register with J-STAGE for free!