Further Highly Hydroxylated Steroids from the Vietnamese Starfish Archaster typicus

Tran Thi Hong Hanh; Le Thi Vien; Le Ba Vinh; Nguyen Van Thanh; Nguyen Xuan Cuong; Nguyen Hoai Nam; Do Cong Thung; Phan Van Kiem; Chau Van Minh

doi:10.1248/cpb.c16-00445

Notes

Further Highly Hydroxylated Steroids from the Vietnamese Starfish Archaster typicus

Tran Thi Hong Hanh, Le Thi Vien, Le Ba Vinh, Nguyen Van Thanh, Nguyen Xuan Cuong , Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh

Author information

Tran Thi Hong Hanh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Le Thi Vien
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Le Ba Vinh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Van Thanh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Xuan Cuong Corresponding author
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hoai Nam
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Do Cong Thung
Institute of Marine Environment and Resources, VAST
Phan Van Kiem
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Chau Van Minh
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

Keywords: Archaster typicus, starfish, polyhydroxylated steroid

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Supplementary material

2016 Volume 64 Issue 10 Pages 1523-1527

DOI https://doi.org/10.1248/cpb.c16-00445

Details

Abstract

Eight highly hydroxylated steroids (1−8), including three new compounds as sodium salts of (24S)-5α-cholestane-3β,4β,5,6α,7β,8,14,15α,24-nonaol 6-sulfate (1), (24E)-5α-cholest-24-ene-26-yde-3β,6α,8,14,15α-pentaol 15-sulfate (2), and 5α-cholest-3β,6α,8,14,15α,24,25,26-octaol 15-sulfate (3), were isolated and elucidated from the methanol extract of the Vietnamese starfish Archaster typicus. The structure elucidation was done by spectroscopic methods including one and two dimensional (1D-, 2D-)NMR and Fourier transform ion cyclotron resonance (FT-ICR)-MS. The isolated compounds can be used as chemical markers for taxonomic identification of the starfish A. typicus.

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