Pyrrole Oligoglycosides from the Starfish Acanthaster planci Suppress Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Macrophages

Le Thi Vien; Tran Thi Hong Hanh; Phan Thi Thanh Huong; Nguyen Hai Dang; Nguyen Van Thanh; Ekaterina Lyakhova; Nguyen Xuan Cuong; Nguyen Hoai Nam; Phan Van Kiem; Alla Kicha; Chau Van Minh

doi:10.1248/cpb.c16-00585

Notes

Pyrrole Oligoglycosides from the Starfish Acanthaster planci Suppress Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Macrophages

Le Thi Vien, Tran Thi Hong Hanh, Phan Thi Thanh Huong, Nguyen Hai Dang, Nguyen Van Thanh, Ekaterina Lyakhova, Nguyen Xuan Cuong , Nguyen Hoai Nam, Phan Van Kiem, Alla Kicha, Chau Van Minh

Author information

Le Thi Vien
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Tran Thi Hong Hanh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Phan Thi Thanh Huong
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hai Dang
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Van Thanh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Ekaterina Lyakhova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences
Nguyen Xuan Cuong Corresponding author
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Hoai Nam
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Phan Van Kiem
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Alla Kicha
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences
Chau Van Minh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

Keywords: Acanthaster planci, starfish, pyrrole oligoglycoside, isolation, nitric oxide (NO) production

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Supplementary material

2016 Volume 64 Issue 11 Pages 1654-1657

DOI https://doi.org/10.1248/cpb.c16-00585

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Abstract

Two new pyrrole oligoglycosides, plancipyrrosides A and B (1 and 2), were isolated from methanol extract of the Vietnamese starfish Acanthaster planci using various chromatographic procedures. Their structures were elucidated by spectroscopic methods including one and two dimensional (1D- and 2D)-NMR and Fourier transform ion cyclotron resonance (FT-ICR)-MS. The finding of 1 and 2 represents the third case of pyrrole oligoglycosides obtaining reported to date. Moreover, plancipyrroside B (2) exhibits a potent inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with IC₅₀ of 5.94±0.34 µM, whereas plancipyrroside A (1) shows this inhibitory activity with IC₅₀ of 16.61±1.85 µM.

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