Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst
Takaaki SakaiShin-ichi HirashimaKosuke NakashimaChie MaedaAkihiro YoshidaYuji KosekiTsuyoshi Miura
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2016 Volume 64 Issue 12 Pages 1781-1784

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Abstract

Diaminomethylenemalononitrile organocatalysts promote the asymmetric chlorination of simple cyclic β-keto esters such as methyl, ethyl, and benzyl esters of 1-oxo-2,3-dihydro-1H-indene-2-carboxylic acid. This affords the corresponding chiral α-chlorinated carbonyl products in excellent yields with high enantioselectivities.

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© 2016 The Pharmaceutical Society of Japan
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