Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Current Topics-Recent Progress in Study on the Biologically-Active Natural Products-
Search for Anti-angiogenic Substances from Natural Sources
Naoyuki KotokuMasayoshi AraiMotomasa Kobayashi
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2016 Volume 64 Issue 2 Pages 128-134

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Abstract

As angiogenesis is critical for tumor growth and metastasis, potent and selective anti-angiogenic agents with novel modes of action are highly needed for anti-cancer drug discovery. In this review, our studies focusing on the search for anti-angiogenic substances from natural sources, such as bastadins, globostellatic acid X methyl esters and cortistatins from marine sponges, and pyripyropenes from marine-derived fungus, together with senegasaponins from medicinal plant, are summarized.

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© 2016 The Pharmaceutical Society of Japan
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