Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

Mohamed S. Abdelfattah; Midori A. Arai; Masami Ishibashi

doi:10.1248/cpb.c16-00038

Special Collection of Papers: Reviews

Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

Mohamed S. Abdelfattah, Midori A. Arai, Masami Ishibashi

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Keywords: actinomycete, isobenzofuran, phenazine, acridine, naphthoquinone, signaling pathway

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2016 Volume 64 Issue 7 Pages 668-675

DOI https://doi.org/10.1248/cpb.c16-00038

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Abstract

Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes our recent study on the isolation of new natural products mainly possessing heterocyclic and aromatic ring structures with biological effects on cancer-related cellular pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) and Wnt signaling.

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