Hyrtinadines C and D, New Azepinoindole-Type Alkaloids from a Marine Sponge Hyrtios sp.

Takaaki Kubota; Kenta Nakamura; Kanae Sakai; Jane Fromont; Tohru Gonoi; Jun’ichi Kobayashi

doi:10.1248/cpb.c16-00201

Special Collection of Papers: Notes

Hyrtinadines C and D, New Azepinoindole-Type Alkaloids from a Marine Sponge Hyrtios sp.

Takaaki Kubota , Kenta Nakamura, Kanae Sakai, Jane Fromont, Tohru Gonoi, Jun’ichi Kobayashi

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Keywords: marine sponge, Hyrtios sp., bisindole, azepinoindole, hyrtinadine, antimicrobial activity

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Supplementary material

2016 Volume 64 Issue 7 Pages 975-978

DOI https://doi.org/10.1248/cpb.c16-00201

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Abstract

New bisindole alkaloids, hyrtinadines C (1) and D (2), have been isolated from an Okinawan marine sponge Hyrtios sp. The structures of hyrtinadines C (1) and D (2) were elucidated based on analyses of the spectral data. Hyrtinadines C (1) and D (2) were the relatively rare alkaloids possessing a 3,4-fused azepinoindole skeleton. Hyrtinadines C (1) and D (2) showed antimicrobial activity.

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