Synthesis of Androprostamine A and Resormycin

Hikaru Abe; Yohko Yamazaki; Chiharu Sakashita; Isao Momose; Takumi Watanabe; Masakatsu Shibasaki

doi:10.1248/cpb.c16-00207

Special Collection of Papers: Notes

Synthesis of Androprostamine A and Resormycin

Hikaru Abe, Yohko Yamazaki, Chiharu Sakashita, Isao Momose, Takumi Watanabe, Masakatsu Shibasaki

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Keywords: antitumor agent, prostate cancer, natural product, synthesis

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Supplementary material

2016 Volume 64 Issue 7 Pages 982-987

DOI https://doi.org/10.1248/cpb.c16-00207

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Abstract

Syntheses of androprostamine A (1), and resormycin (3), anti-prostate cancer peptidyl natural products produced by microorganisms, were completed. The characteristic enamide structures of these compounds were installed using the Horner-Wadsworth-Emmons reaction from the corresponding phosphonates in reasonable Z-selectivity.

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