Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Synthesis and Structural Revision of Cyslabdan
Masaki OhtawaYusuke HishinumaEiji TakagiTakafumi YamadaFumihiro ItoShiho ArimaRyuji UchidaYong-Pil KimSatoshi ŌmuraHiroshi TomodaTohru Nagamitsu
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2016 Volume 64 Issue 9 Pages 1370-1377

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Abstract

Cyslabdan was isolated from the culture broth of Streptomyces sp. K04-0144 as a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus. We accomplished the synthesis of cyslabdan according to a previously reported structure. However, we subsequently found that this structure was incorrect; our analysis of natural cyslabdan showed that it possessed R stereochemistry at the C8 position, not S, as had previously been reported. Thus, we completed the protecting-group-free synthesis of the correct structure of cyslabdan, which is described herein.

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© 2016 The Pharmaceutical Society of Japan
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