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Chemical and Pharmaceutical Bulletin
Vol. 65 (2017) No. 1 p. 19-21

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http://doi.org/10.1248/cpb.c16-00333

Current Topics: Communications to the Editor

A highly chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester using a soft Lewis acid/hard Brønsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcohols, including unprecedented cyclic β-amino alcohol, were applicable to the present catalysis.

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Copyright © 2017 The Pharmaceutical Society of Japan

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