DNA Topoisomerase Inhibitory Activity of Constituents from the Fruits of Illicium verum

Tae In Kim; Bora Shin; Geum Jin Kim; Hyukjae Choi; Chong Soon Lee; Mi Hee Woo; Dong-Chan Oh; Jong Keun Son

doi:10.1248/cpb.c17-00466

Notes

DNA Topoisomerase Inhibitory Activity of Constituents from the Fruits of Illicium verum

Tae In Kim, Bora Shin, Geum Jin Kim, Hyukjae Choi, Chong Soon Lee, Mi Hee Woo, Dong-Chan Oh, Jong Keun Son

Author information

Keywords: Illicium verum, topoisomerase I, topoisomerase II, cytotoxicity

JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2017 Volume 65 Issue 12 Pages 1179-1184

DOI https://doi.org/10.1248/cpb.c17-00466

Browse “Advance online publication” version

Details

Abstract

Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4–10), were isolated from the fruits of Illicium verum HOOK. FIL. (Illiciaceae). The structures of 1–3 were determined based on one and two dimensional (1D- and 2D-) NMR data and electronic circular dichroism (ECD) spectra analyses. Compounds 3, 5, 6, and 8–10 exhibited potent inhibitory activities against topoisomerase II with IC₅₀ values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 µM, respectively, compared to etoposide, the positive control, with an IC₅₀ of 43.8 µM.

Graphical Abstract Fullsize Image

Corresponding author

Register with J-STAGE for free!