Synthesis of Novel Heterocyclic Compounds Incorporate 4,5,6,7-Tetrahydrobenzo[b]thiophene Together with Their Cytotoxic Evaluations

Amira Elsayed Mahmoud Abdallah; Rafat Milad Mohareb; Eid Metwally Khalil; Menna Alla Mohamed Abd Elaleem Elshamy

doi:10.1248/cpb.c16-00925

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Synthesis of Novel Heterocyclic Compounds Incorporate 4,5,6,7-Tetrahydrobenzo[b]thiophene Together with Their Cytotoxic Evaluations

Amira Elsayed Mahmoud Abdallah , Rafat Milad Mohareb, Eid Metwally Khalil, Menna Alla Mohamed Abd Elaleem Elshamy

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Keywords: tetrahydrobenzo[b]thiophene, cytotoxic evaluation, multicompounant reaction, pyrimidine, thiazole

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2017 Volume 65 Issue 5 Pages 469-477

DOI https://doi.org/10.1248/cpb.c16-00925

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Abstract

The 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene was the key starting compound used to synthesize new thiazole, pyrimidine, pyran, pyridine and thiazine derivatives. The cytotoxicity of the synthesized compounds was studied towards the three cancer cell lines namely MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (central nervous system (CNS) cancer) in addition to the normal cell line (WI-38) using doxorubicin as the reference drug. The study showed that compounds 5, 9a, 15b, 17c, 18 and 21b were the most potent compounds.

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