Total Synthesis of Carbazomycins A and B

Abstract

Total syntheses of carbazomycins A and B were demonstrated using a ytterbium-catalyzed Diels–Alder reaction with (silyloxyvinyl)indole as a diene. The densely substituted benzene ring of the target compound was successfully constructed by functionalization of a hydrocarbazolone intermediate and subsequent aromatization using N-bromosuccinimide.

Graphical Abstract