Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells
Zhenjiang Xia, Lixin Wei, Yuzhi Du, Lulu Wang, Jichun Han, Qiangqiang He, Haijuan Chen, Xiaoyan Zou, Huali Wu, Jing Shang
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Keywords: Tibetan medicine, Zuotai, mercury, cytotoxicity, RBL-2H3 cell
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2018 Volume 66 Issue 8 Pages 818-821

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Abstract

Zuotai is a drug containing mercury considered to be the king of Tibetan medicine. The biosafety of Zuotai led people’s attention and so far little is known about the toxicity of Zuotai to mast cells. RBL-2H3 cells which used as an alternative model of mast cells were treated with Zuotai, β-HgS and positive drug Compound 48/80 respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the toxicity of drugs to RBL-2H3 cells. The degranulation of RBL-2H3 cells was studied from β-hexosaminidase, histamine, interleukin (IL)-4 and tumor necrosis factor-α (TNF-α). The result showed that Zuotai can affect the cytotoxicity and degranulation of RBL-2H3 cells and the results can provide reference for the toxicity evaluations of Tibetan medicine Zuotai.

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© 2018 The Pharmaceutical Society of Japan
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