2019 Volume 67 Issue 1 Pages 18-22
In our quest for structurally intriguing compounds from Korean medicinal plant sources, chromatographic separation of the 80% MeOH extract from Firmiana simplex resulted in the isolation and identification of three new lignan glycosides (1–3), together with six known lignan glycosides (4–9). The structures of 1–3 were determined on the basis of spectroscopic analyses, including extensive 2D-NMR and enzyme hydrolysis. Nitric oxide (NO) production was evaluated in the lipopolysaccharide-activated microglial cell line, BV-2 to investigate the anti-neuroinflammatory effects of the isolated compounds (1–9). Compound 7 marginally inhibited NO levels with IC50 values of 59.83 µM.
