Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Current Topics: Review
A Review on the Foodomics Based on Liquid Chromatography Mass Spectrometry
Yoshio MugurumaMari NunomeKoichi Inoue
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2022 Volume 70 Issue 1 Pages 12-18


Due to the globalization of food production and distribution, the food chain has become increasingly complex, making it more difficult to evaluate unexpected food changes. Therefore, establishing sensitive, robust, and cost-effective analytical platforms to efficiently extract and analyze the food-chemicals in complex food matrices is essential, however, challenging. LC/MS-based metabolomics is the key to obtain a broad overview of human metabolism and understand novel food science. Various metabolomics approaches (e.g., targeted and/or untargeted) and sample preparation techniques in food analysis have their own advantages and limitations. Selecting an analytical platform that matches the characteristics of the analytes is important for food analysis. This review highlighted the recent trends and applications of metabolomics based on “foodomics” by LC-MS and provides the perspectives and insights into the methodology and various sample preparation techniques in food analysis.

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© 2022 The Pharmaceutical Society of Japan
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