Anti-hepatitis C Virus Activity of Juglorubin Derivatives

Hirofumi Ohashi; Kazane Nishioka; Tomoki Kurihara; Kou Nakamura; Masako Yamasaki; Yuuka Ibayashi; Kanta Fuchiyama; Shogo Kamo; Yuuki Furuyama; Kenji Ohgane; Maiko Okada; Shinji Kamisuki; Koichi Watashi; Kouji Kuramochi

doi:10.1248/cpb.c23-00489

Notes

Anti-hepatitis C Virus Activity of Juglorubin Derivatives

Hirofumi Ohashi, Kazane Nishioka, Tomoki Kurihara, Kou Nakamura, Masako Yamasaki, Yuuka Ibayashi, Kanta Fuchiyama, Shogo Kamo, Yuuki Furuyama, Kenji Ohgane, Maiko Okada, Shinji Kamisuki, Koichi Watashi , Kouji Kuramochi

Author information

Hirofumi Ohashi
Department of Applied Biological Science, Tokyo University of Science
Department of Virology II, National Institute of Infectious Diseases
Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
Kazane Nishioka
Department of Applied Biological Science, Tokyo University of Science
Department of Virology II, National Institute of Infectious Diseases
Tomoki Kurihara
Department of Applied Biological Science, Tokyo University of Science
Department of Virology II, National Institute of Infectious Diseases
Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
Kou Nakamura
School of Veterinary Medicine, Azabu University
Masako Yamasaki
Department of Applied Biological Science, Tokyo University of Science
Department of Virology II, National Institute of Infectious Diseases
Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
Yuuka Ibayashi
Department of Applied Biological Science, Tokyo University of Science
Kanta Fuchiyama
Department of Applied Biological Science, Tokyo University of Science
Shogo Kamo
Department of Applied Biological Science, Tokyo University of Science
Department of Synthetic Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
Yuuki Furuyama
Department of Applied Biological Science, Tokyo University of Science
Kenji Ohgane
Department of Applied Biological Science, Tokyo University of Science
Department of Chemistry, Ochanomizu University
Maiko Okada
School of Bioscience and Biotechnology, Tokyo University of Technology
Shinji Kamisuki
School of Veterinary Medicine, Azabu University
Center for Human and Animal Symbiosis Science, Azabu University
Koichi Watashi Corresponding author
Department of Applied Biological Science, Tokyo University of Science
Department of Virology II, National Institute of Infectious Diseases
Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases
Kouji Kuramochi Corresponding author
Department of Applied Biological Science, Tokyo University of Science

Keywords: juglorubin, hepatitis C virus, liver X receptor

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Supplementary material

2023 Volume 71 Issue 11 Pages 843-845

DOI https://doi.org/10.1248/cpb.c23-00489

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Abstract

Juglorubin is a natural dye isolated from the culture of Streptomyces sp. 3094, 815, and GW4184. It has been previously synthesized via the biomimetic dimerization of juglomycin C, a plausible genetic precursor. In this study, the derivatives of juglorubin, 1-O-acetyljuglorubin dimethyl ester and juglorubin dimethyl ester, were found to exhibit antiviral activity against hepatitis C virus (HCV) without exerting any remarkable cytotoxicity against host Huh-7 cells. They also inhibited liver X receptor α activation and lipid droplet accumulation in Huh-7 cells. These findings suggest that 1-O-acetyljuglorubin dimethyl ester and juglorubin dimethyl ester targeted the host factors required for HCV production.

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