Development of Frontier Artificial Nucleoside Derivatives through Precise Nucleic Acid Recognition for Drug Discovery

Abstract

Artificial nucleic acids—engineered through fine-tuned molecular design based on organic synthetic chemistry and focused on nucleic acid molecular recognition—show significant potential in drug discovery, especially in the development of nucleic acid therapeutics and drugs. This review underscores recent advancements in nucleic acid chemistry achieved by our research group, including the design of novel artificial nucleoside analogs, exploration of their applications, and elucidation of their molecular functions.