Speradines F–H, Three New Oxindole Alkaloids from the Marine-derived Fungus Aspergillus Oryzae

Xiao Hu; Qi-Wen Xia; Yang-Yang Zhao; Qiu-Hong Zheng; Qin-Ying Liu; Li Chen; Qi-Qing Zhang

doi:10.1248/cpb.c14-00312

This article has now been updated. Please use the final version.

Speradines F–H, Three New Oxindole Alkaloids from the Marine-derived Fungus Aspergillus Oryzae

Xiao Hu, Qi-Wen Xia, Yang-Yang Zhao, Qiu-Hong Zheng, Qin-Ying Liu, Li Chen , Qi-Qing Zhang

Author information

Xiao Hu
Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University
The School of Pharmacy, Fujian University of Traditional Chinese Medicine
Qi-Wen Xia
Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University
Yang-Yang Zhao
Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University
Qiu-Hong Zheng
Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Cancer Hospital
Qin-Ying Liu
Fujian Provincial Key Laboratory of Tumor Biotherapy, Fujian Provincial Cancer Hospital
Li Chen Corresponding author
Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University
Qi-Qing Zhang
Institute of Biomedical and Pharmaceutical Technology, College of Chemistry and Chemical Engineering, Fuzhou University
Institute of Biomedical Engineering, Chinese Academy of Medical Science, Peking Union Medical College

Keywords: speradine, oxindole alkaloid, Aspergillus oryzae; marine-derived fungus

JOURNAL FREE ACCESS FULL-TEXT HTML Advance online publication

Article ID: c14-00312

DOI https://doi.org/10.1248/cpb.c14-00312

The final version of this article is now available: Vol. 62 (2014), No. 9 pp. 942-946

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Abstract

A rare hexacyclic oxindole alkaloid, speradine F (1), together with two novel tetracyclic oxindole alkaloids, speradines G (2) and H (3) , were isolated from the marine-derived fungus Aspergillus oryzae. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. This study is the first report on cyclopiazonic acid (CPA)-type alkaloids with a hexacyclic skeleton.

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