Studies on Decomposition and Stabilization of Drugs in Solution. XI. Overall Velocity Constants for Succinylmonocholine Chloride Hydrolysis as a Function of pH.

Abstract

1) The degradative reaction of succinylmonocholine chloride, the first hydrolytic product of succinylcholine chloride, was investigated over the whole pH range of 0.5 to 8.5 from the standpoint of chemical kinetics. The degradation is an apparent monomolecular reaction at a fixed pH value.
2) The decomposition may be accounted for by the six rate constants of bimolecular reaction and the dissociation constant of succinylmonocholine chloride. The rate (hr.^-1) of reaction at 60° can be practically represented by
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The relatively slight variation in k caused by buffer effect as compared with succinylcholine chloride was recognized.
3) The hydrolysis of succinylcholine chloride in aqueous solution at a fixed pH value was fitted to a kinetic expression for a consecutive reaction with two first-order reactions. A good agreement was obtained between calculated and experimental values.