Metabolism of Drugs. XXXIII. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid.(1)

Abstract

1. The ring structure of p-aminobenzoyl glucuronide isolated from the dog urine was confirmed through the synthetic experiment on methyl (p-acetamidobenzoyl-2, 3, 4-tri-O-acetyl-β-D-glucopyranosid) uronate. It was concluded that p-aminobenzoyl glucuronidehas a pyranose configuration.
2. p-Aminobenzoyl glucuronide isolated from the dog urine was rapidly hydrolyzed by a rabbit-liver β-glucuronidase preparation.