Studies on the Synthesis of New Antimicrobials. II. Syntheses of 3-(5-Nitro-2-thienyl) acrylic Acid Derivatives and their Some Antibacterial Activities

Abstract

3-(5-Nitro-2-thienyl) acrylic acid was synthesized in good yield by direct nitration of 3-(2-thienyl) acrylic acid obtained from 2-thiophenecarboxaldehyde without proceeding through 5-nitro-2-thiophenecarboxaldehyde diacetate. By condensation of the acid with various amines, alcohols or phenols, its amide and ester derivatives were prepared. 2-Bromo-3-(5-nitro-2-thienyl) acrylic acid esters were also obtained by bromination of the corresponding esters.
Antibacterial activity of these compounds was tested on some bacteria in vitro.