Studies on Oxidized Starch Sulfates for Medical Purposes. I. Synthesis of Sulfates of Oxidized Starch and its Derivatives.

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In order to obtain the heparin-like active substances, the sulfates of oxidized starch, obtained by oxidation with nitric acid and its derivatives, were prepared by the reaction with formamide and chlorosulfonic acid. Sulfate of reduced product of oxidized starch, sulfates of oxidized starch amine, sulfates of methyl ester of reduced product of oxidized starch and its reduced product, and demethyl product were also prepared. Reduced product of oxidized starch is found more suitable as a starting material to prepare the heparin-like substances, because reduced product of oxidized starch having no carbonyl group is more stable against degradation during sulfation.