抄録
The Grignard reaction of 17β-hydroxy-17α-methylestr-4-en-3-one (VIIa) in the presence of cuprous chloride gave 5β, 17α-dimethyl-17β-hydroxyestran-3-one (VIIIa) and 3, 17α-dimethylestra-3, 5-dien-17β-ol (Xa). Similarly, (VIIIb) and (Xb) were obtained by the Grignard reaction of 17β-hydroxyestr-4-en-3-one (VIIb). The oxidation of (VIIIb) with chromium trioxide gave 5β-methyl-estrane-3, 17-dione (XI). Discussion was made on the configuration of C-5 methyl group in (VIIIa) and (VIIIb).
